Tamil Nadu has 39 Government medical Colleges (including 1 AIIMS) accepting NEET UG and offering MBBS Course, The Best Government Medical colleges in Tamil Nadu are Madras Medical College,Chennai, Stanley Medical College, Chennai, Madurai Medical College, Madurai, Thanjavur Medical College, Thanjavur, Kilpauk Medical College, Chennai, Tirunelvelli Medical College, Tirunelvelli, Rajah Muthiah Medical College, Annamalainagar, Chengalpattu Medical College, Chengalpattu, Coimbatore Medical College, Coimbatore. In Tamil Nadu total 5350 MBBS Seats available in Government Medical Colleges.
| S. N | College Name | Estd | Total Intake |
| 1 | AIIMS Madurai | 2021 | 50 |
| 2 | Annaii Medical College and Hospital, Kancheepuram Distt | 2024 | 100 |
| 3 | Chengalpattu Medical College, Chengalpattu | 1965 | 100 |
| 4 | Coimbatore Medical College, Coimbatore | 1966 | 200 |
| 5 | E.S.I.C. Medical College & Hospital, K.K. Nagar, Chennai earlier known as ESIC Medical College & PGIMSR, K.K Nagar, Chennai | 2013 | 150 |
| 6 | Government Medical College, Ariyalur | 2021 | 150 |
| 7 | Government Dharmapuri Medical College, Dharmapuri | 2008 | 100 |
| 8 | Government Erode Medical College & Hospital, Perundurai (Formerly IRT Perundurai Medical College) | 1992 | 100 |
| 9 | Government Medical College & ESIC Hospital, Coimbatore | 2016 | 100 |
| 10 | Government Medical College, Dindigul | 2021 | 150 |
| 11 | Government Medical College, Kallakurichi | 2021 | 150 |
| 12 | Government Medical College, Karur | 2019 | 150 |
| 13 | Government Medical College, Krishnagiri | 2021 | 150 |
| 14 | Government Medical College, Nagapattinam | 2021 | 150 |
| 15 | Government Medical College, Namakkal | 2021 | 100 |
| 16 | Government Medical College, Omandurar | 2015 | 100 |
| 17 | Government Medical College, Pudukottai | 2017 | 150 |
| 18 | Government Medical College, Ramanathapuram | 2021 | 100 |
| 19 | Government Sivaganga Medical College, Sivaganga | 2012 | 100 |
| 20 | Government Medical College ,Tiruppur | 2021 | 100 |
| 21 | Government Medical College, The Nilgiris | 2021 | 150 |
| 22 | Government Medical College, Thiruvallur | 2021 | 100 |
| 23 | Govt. Mohan Kumaramangalam Medical College, Salem | 1986 | 100 |
| 24 | Government Thiruvannnamalai Medical College, Thiruvannamali | 2013 | 100 |
| 25 | Government Vellore Medical College, Vellore | 2005 | 100 |
| 26 | Government Villupuram Medical College, Villupuram | 2010 | 100 |
| 27 | Government Medical College, Virudhunagar | 2021 | 150 |
| 28 | KanyaKumari Government College, Asaripallam | 2003 | 150 |
| 29 | KAP Vishwanathan Government Medical College, Tirichy | 1998 | 150 |
| 30 | Kilpauk Medical College, Chennai | 1960 | 150 |
| 31 | Madras Medical College, Chennai | 1835 | 250 |
| 32 | Madurai Medical College, Madurai | 1954 | 250 |
| 33 | Rajah Muthiah Medical College, Annamalainagar | 1985 | 150 |
| 34 | Stanley Medical College, Chennai | 1838 | 250 |
| 35 | Thanjavur Medical College, Thanjavur | 1959 | 150 |
| 36 | Theni Government Medical College, Theni | 2006 | 100 |
| 37 | Thiruvarur Government Medical College, Thiruvarur | 2010 | 100 |
| 38 | Thoothukudi Medical College, Thoothukudi | 2000 | 150 |
| 39 | Tirunelveli Medical College, Tirunelveli | 1965 | 250 |
| Total Number of MBBS Seats of Government Medical Colleges in Tamil Nadu | 5350 | ||